Open AccessThe 1 mg overnight dexamethasone suppression test: a danger to the adrenal gland?
Author(s) -
Chaim Vanek,
Lynn Loriaux
Publication year - 2022
Publication title -
current opinion in endocrinology, diabetes and obesity./current opinion in endocrinology, diabetes and obesity
Language(s) - English
Resource type - Journals
eISSN - 1752-2978
pISSN - 1752-296X
DOI - 10.1097/med.0000000000000752
Subject(s) - dexamethasone , adrenal gland , endocrinology , dexamethasone suppression test , medicine , test (biology) , biology , paleontology
The 1 mg overnight dexamethasone suppression test (ONDST) with a cutoff cortisol value of 1.8 mcg/dl (50 nmol/l) is routinely used for the assessment of incidental, benign adrenal nodules. Patients with an abnormal test are diagnosed with mild autonomous cortisol secretion (MACS). This timely commentary reviews the origins of the ONDST, its relationship to the diagnoses of MACS, and whether this is clinically relevant for clinical care.