Open AccessNutritional ketosis is well-tolerated, even in type 1 diabetes: the ZeroFive100 Project; a proof-of-concept study
Author(s) -
Ian Lake
Publication year - 2021
Publication title -
current opinion in endocrinology, diabetes and obesity./current opinion in endocrinology, diabetes and obesity
Language(s) - English
Resource type - Journals
eISSN - 1752-2978
pISSN - 1752-296X
DOI - 10.1097/med.0000000000000666
Subject(s) - ketosis , type 1 diabetes , medicine , ketone bodies , diabetes mellitus , diabetic ketoacidosis , respiratory quotient , ketoacidosis , mood , endocrinology , pediatrics , metabolism , psychiatry
The objective of this study was to test the feasibility of exercising over a 5-day period while fasting, in those with and without type 1 diabetes mellitus (T1DM).Eight individuals, ages 29--62 years, two with T1DM, walked/ran around 20 miles per day for five consecutive days while only consuming water. All eight individuals completed the project with no physical injuries or problems with diabetes control. The blood glucose levels ranged from less than 3 mmol/l to 7 mmol/l in those without T1D, and less than 3 mmol/l to 9 mmol/l in those with T1D. The continuous glucose traces in those with T1D showed little variability in glucose levels. The participants without T1D had no symptoms from blood glucose under 3 mmol/l. Ketone levels ranged from 0.3 to 7.5 and the ketones for those with T1D were no different to ketones in those without T1D. The respiratory quotient was overwhelmingly in the fat-burning range. There was very little subjective hunger, nor did it negatively affect mood. In keto-adapted individuals, with or without T1DM, prolonged exercise for 5 days while in nutritional ketosis was feasible, and well tolerated.