Open AccessThe role of endocrine-disrupting chemicals in uterine fibroid pathogenesis
Author(s) -
María Victoria Bariani,
Roshni Rangaswamy,
Hiba Siblini,
Qiwei Yang,
Ayman AlHendy,
Ami R. Zota
Publication year - 2020
Publication title -
current opinion in endocrinology, diabetes and obesity./current opinion in endocrinology, diabetes and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.199
H-Index - 67
eISSN - 1752-2978
pISSN - 1752-296X
DOI - 10.1097/med.0000000000000578
Subject(s) - endocrine system , medicine , uterine fibroids , diethylstilbestrol , infertility , gynecology , pathogenesis , physiology , animal studies , pregnancy , estrogen , hormone , biology , genetics
Uterine leiomyoma (fibroids) is a gynecologic disorder impacting the majority of women in the United States. When symptomatic, these noncancerous tumors can cause severe morbidity including pelvic pain, menorrhagia, and infertility. Endocrine-disrupting chemicals (EDCs) may represent a modifiable risk factor. The aim of this review is to summarize recent human and experimental evidence on EDCs exposures and fibroids.