Open AccessThe role of beta-cell dysfunction in early type 1 diabetes
Author(s) -
Emily K. Sims,
Raghavendra G. Mirmira,
Carmella EvansMolina
Publication year - 2020
Publication title -
current opinion in endocrinology, diabetes and obesity./current opinion in endocrinology, diabetes and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.199
H-Index - 67
eISSN - 1752-2978
pISSN - 1752-296X
DOI - 10.1097/med.0000000000000548
Subject(s) - disease , medicine , diabetes mellitus , cell , beta cell , bioinformatics , neuroscience , immunology , biology , endocrinology , islet , genetics
Emerging data have suggested that β-cell dysfunction may exacerbate the development and progression of type 1 diabetes (T1D). In this review, we highlight clinical and preclinical studies suggesting a role for β-cell dysfunction during the evolution of T1D and suggest agents that may promote β-cell health in T1D.