Open AccessEndotypes in T1D: B lymphocytes and early onset
Author(s) -
Mia J. Smith,
John C. Cambier,
Peter Gottlieb
Publication year - 2020
Publication title -
current opinion in endocrinology, diabetes and obesity./current opinion in endocrinology, diabetes and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.199
H-Index - 67
eISSN - 1752-2978
pISSN - 1752-296X
DOI - 10.1097/med.0000000000000547
Subject(s) - immunology , disease , autoimmunity , islet , b cell , antigen , medicine , biology , diabetes mellitus , immune system , endocrinology , antibody
Although type 1 diabetes (T1D) is characterized by destruction of the pancreatic beta cells by self-reactive T cells, it has become increasingly evident that B cells also play a major role in disease development, likely functioning as antigen-presenting cells. Here we review the biology of islet antigen-reactive B cells and their participation in autoimmune diabetes.