Open AccessThe prognosis and incidence of hepatic encephalopathy of patients with liver cirrhosis treated with proton pump inhibitors
Author(s) -
Akira Sakamaki,
Kenya Kamimura,
Takeshi Yokoo,
Akihiko Osaki,
Seiichi Yoshikawa,
Yoshihisa Arao,
Toru Setsu,
Hiroteru Kamimura,
Nobuo Waguri,
Manabu Takeuchi,
Kazuhiro Funakoshi,
Shuji Terai
Publication year - 2021
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000026902
Subject(s) - medicine , gastroenterology , hepatic encephalopathy , cirrhosis , propensity score matching , hazard ratio , incidence (geometry) , retrospective cohort study , proton pump inhibitor , confidence interval , physics , optics
Gastrointestinal bleeding, hepatic encephalopathy (HE), and hepatocarcinogenesis are associated with the prognosis of patients with liver cirrhosis (LC). Proton pump inhibitors (PPIs) have been used to prevent bleeding, however the effects of PPIs on overall survival have not yet been elucidated. Therefore, this multicenter retrospective study aimed to assess the effect of PPI on the prognosis and HE occurrence of the patients with liver cirrhosis in Japan. A total of 456 patients diagnosed with LC at the 4 institutes during the study period (2010–2014) were assessed. PPI-treated and non-treated patients were compared using propensity score matching analysis. Primary and secondary endpoints of the study were set as the occurrence of HE and overall survival, respectively. A comparison of all cases showed a significantly poorer hepatic reserve function in the PPI-treated patients. The propensity-score matching analysis was performed and 120 PPI-treated patients were 1:1 matched with non-treated patients. The analysis revealed a higher incidence of HE in the PPI-treated than in the non-treated patients ( P = .032; hazard ratio [HR], 2.162; 95% confidence interval [CI], 1.066–4.176), but the prognosis of PPI-treated patients was no worse than that of non-treated patients ( P = .676; HR, 1.101; 95% CI, 0.702–1.726). This retrospective study showed that PPI administration for the patients with liver cirrhosis may partly be related to the increased incidence of HE but not worsen the patient prognosis.