Open AccessEffects of ABCB1 gene polymorphism on the efficacy of antidepressant drugs
Author(s) -
Xiaoying Zheng,
Zejuan Fu,
Xiaomei Chen,
Mingxia Wang,
Rixia Zhu
Publication year - 2021
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000026411
Subject(s) - medicine , meta analysis , odds ratio , antidepressant , confidence interval , depression (economics) , medline , bioinformatics , pharmacology , oncology , traditional medicine , psychiatry , biology , biochemistry , hippocampus , economics , macroeconomics
Background: Antidepressant drugs are mainly used to treat depression clinically. ABCB1 affects the P-glycoprotein activity and changes the amount of drugs in the blood tissue barrier that can be squeezed back into the blood, thus affecting the efficacy of antidepressants. In this present study, Meta-analysis was performed to further investigate the influences of ABCB1 gene polymorphism on antidepressant response. Methods: Relevant literatures were searched from the PubMed, EMBASE, Web of Science, Chinese National Knowledge Infrastructure, Chinese Science and Technique Journals Database, China Biology Medicine disc, and Wan Fang databases up to May 2021 without any language restrictions. STATA 16.0 software was applied for this meta-analysis. Odds ratio (OR) and its corresponding 95% confidence interval (CI) were calculated. Results: The results of this meta-analysis will be submitted to a peer-reviewed journal for publication. Conclusion: This meta-analysis will summarize the effects of ABCB1 gene polymorphism on antidepressant response.