Open AccessIdentification of prognostic tumor-infiltrating immune cells in endometrial adenocarcinoma
Author(s) -
Xin-Bin Pan,
Yan Lu,
DeSheng Yao
Publication year - 2021
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000026170
Subject(s) - adenocarcinoma , medicine , immune system , endometrial cancer , cd8 , tumor infiltrating lymphocytes , oncology , endometrium , cancer research , cancer , immunology
To identify prognostic tumor-infiltrating immune cells of endometrial adenocarcinoma. The gene expression profiles of endometrial adenocarcinoma were downloaded from the Cancer Genome Atlas (TCGA). The abundance of tumor-infiltrating immune cells in endometrial adenocarcinoma samples was calculated by CIBERSORT algorithm. Kaplan–Meier analysis was used to identify prognostic tumor-infiltrating immune cells. This study identified 22 kinds of tumor-infiltrating immune cells. Macrophages M0 and CD8 T cells were prognostic factors of endometrial adenocarcinoma. The abundance of macrophages M0 ( P = .038) was significantly correlated with better prognosis of endometrial adenocarcinoma. In contrast, the abundance of CD8 T cells ( P = .049) was associated with poor prognosis of endometrial adenocarcinoma. Tumor-infiltrati macrophages M0 and CD8 T cells were prognostic factors of endometrial adenocarcinoma.