Open AccessEffects of omalizumab in children with asthma
Author(s) -
Lu Chen,
Yanping Chen
Publication year - 2021
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000026155
Subject(s) - omalizumab , medicine , asthma , systematic review , medline , cochrane library , spirometry , emergency department , meta analysis , tolerability , data extraction , intensive care medicine , pediatrics , adverse effect , immunology , immunoglobulin e , nursing , antibody , political science , law
Background: It is still controversial in the current literature whether omalizumab is beneficial for children with asthma. Given that there is no high-quality meta-analysis to incorporate existing evidence, the purpose of this protocol is to design a systematic review and meta-analysis of the level I evidence to ascertain whether omalizumab is beneficial and safe for children with asthma. Methods: The systematic literature review is structured to adhere to Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. The following search terms will be used in PUBMED, Scopus, EMBASE, and Cochrane Library databases on June, 2021, as the search algorithm: (omalizumab) AND (asthma) AND (children). The primary outcome is the long-term safety and tolerability of omalizumab. The other outcomes include asthma control, quality of life, use of asthma controller medications, and spirometry measurements and emergency room visits due to asthma, and serum trough concentrations of omalizumab, free and total immunoglobulin E measured. Review Manager software (v 5.3; Cochrane Collaboration) will be used for the meta-analysis. Results: The review will add to the existing literature by showing compelling evidence and improved guidance in clinic settings. Registration number: 10.17605/OSF.IO/G6N3P.