Open AccessThe efficacy and safety of beta-blockers versus cyanoacrylate injection for gastric variceal bleeding
Author(s) -
Yu-bao Sun,
Sheng Li,
Feng Li
Publication year - 2021
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000026039
Subject(s) - medicine , cyanoacrylate , cochrane library , bleed , gastric varices , meta analysis , randomized controlled trial , observational study , medline , systematic review , portal hypertension , surgery , cirrhosis , chemistry , adhesive , organic chemistry , layer (electronics) , political science , law
Background: The benefit of beta-blockers for secondary prophylaxis of gastric variceal bleeding has limited evidence. Therefore, a systematic review and meta-analysis was conducted to systematically analyze and compare the effect of beta-blockers versus cyanoacrylate injection for patients with gastric variceal bleeding. Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses reporting guidelines will be followed to conduct the present meta-analysis. From the inception to June 2021, the Web of Science, EMBASE, PubMed, and Cochrane Library electronic databases will be searched using the key phrases “beta-blockers,” “cyanoacrylate,” and “gastric variceal bleeding” for all relevant English-language trials. Study included in our meta-analysis has to meet the following criteria: observational or randomized controlled trial focusing on assessing the effectiveness of beta-blockers and cyanoacrylate injection for gastric variceal bleeding; the following outcome measures are reported: bleeding from gastric variceal, overall mortality, bleed related mortality, and complications. Results: This study expects to provide credible and scientific evidence for the efficacy and safety of beta-blockers versus cyanoacrylate injection for patients with gastric variceal bleeding. Registration number: 10.17605/OSF.IO/CPV9T.