Open AccessAn intracapsular nephrectomy for the acquired cystic disease-associated renal cell carcinoma in renal transplant allograft
Author(s) -
Song Yue,
Jingjing Zheng,
Shiying Guo,
Lianhui Fan
Publication year - 2021
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000025858
Subject(s) - medicine , nephrectomy , cystic kidney disease , renal cell carcinoma , kidney , transplantation , hemodialysis , kidney transplantation , urology , kidney disease , bilateral nephrectomy , surgery , pathology
Rationale: Acquired cystic disease-associated renal cell carcinoma (ACKD-RCC) is a unique subtype of renal cell carcinoma (RCC) and is found exclusively in patients with end-stage renal disease. We report a case of intracapsular nephrectomy (ICAN) of renal allograft with ACKD-RCC. To our knowledge, this is the first case in Asia of ICAN of renal allograft to treat ACKD-RCC. Patient concerns: A 51-year-old male patient with a history of allogeneic kidney transplantation (23 years previously) presented with renal cystic degeneration of the transplanted kidney over the past 2 years. Diagnoses: ICAN was used to remove the cystic kidney. Interventions: The pathology report indicated clear cell renal cell carcinoma. Outcomes: Two years after surgery, computed tomography showed no tumor recurrence, and the patient's creatinine level was 3.5 mg/dl under hemodialysis. Lessons: Removal of transplanted kidney with ACKD-RCC using ICAN is feasible to provide a mid-term tumor-free survival for the patient. Therefore, we consider nephrectomy as an early treatment for the nonfunctional cystic allograft kidney, in order to reduce the dosage of anti-rejection drugs, avoid the occurrence of transplanted kidney tumor, and provide the possibility for the patient an opportunity to receive a second kidney transplantation.