Open AccessMultidisciplinary treatment of primary intracranial yolk sac tumor
Author(s) -
Zhen-Ning Xu,
Xiang-yong Yue,
Xiaoci Cao,
Ya-Dong Liu,
Baoshuan Fang,
Wenzhi Zhao,
Chen Li,
Shuai Xu,
Ming Zhang
Publication year - 2021
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000025778
Subject(s) - medicine , radiosurgery , radiation therapy , magnetic resonance imaging , radiology , surgery
Rationale: Intracranial yolk sac tumors (YSTs) are rare malignancies with limited treatment options and a dismal prognosis. They are usually managed with surgical resection and chemoradiotherapy. Patient concerns: Here, we report a patient with primary YST in the pineal region who achieved long term survival. Despite undergoing treatment, he experienced several recurrences over a 15-year period. Diagnosis: Brain magnetic resonance imaging (MRI) demonstrated the presence of space-occupying lesions in the pineal region and the medial tail of the left lateral ventricle. The tumors were excised, and the histological diagnosis suggested an intracranial YST. Interventions: The patient achieved long term survival after combined modality therapy including surgery, stereotactic radiosurgery (SRS)/intensity modulated radiation therapy (IMRT), chemotherapy, and targeted therapy. Outcomes: The disease remained stable. However, the patient gave up treatment and passed away in October 2020, with a total survival of about 15 years. Lessons: To the best of our knowledge, this patient with intracranial YST had received a longer survival compared with other published reports. We summarize previously published reports of intracranial YST and discuss the importance of multidisciplinary treatment. SRS may have a role, as a focal boost to residual tumor after resection or in case of recurrence after conventional radiotherapy, in the multimodality management of intracranial YSTs.