Open AccessA case report of aggressive course of CD30+ primary cutaneous anaplastic large cell lymphoma
Author(s) -
Wen-Tian Lyu,
Song Qi-bin,
Qiong Wang,
Jing Liu,
Ren Yong,
Fengtao Yi,
Deping Han
Publication year - 2021
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000025770
Subject(s) - medicine , cd30 , anaplastic large cell lymphoma , radiation therapy , lymphoma , large cell , pathology , lesion , large cell lymphoma , regimen , cancer , adenocarcinoma
Abstract Introduction: CD30+ primary cutaneous anaplastic large cell lymphoma (PC-ALCL) is a rare T-cell neoplasm, and has been reported to present with an indolent behavior. The PC-ALCL with aggressive behavior has not been reported in the literature. Patient concerns: We treated a patient with PC-ALCL that exhibited indolent behavior in the past 2 years and aggressive behavior within the last 3 months before presentation. Diagnosis: Aggressive CD30+ primary cutaneous anaplastic large cell lymphoma. Interventions: The radiotherapy regimen was individualized in terms of the target volume delineation and dose prescription, and the dose–response relationship was evaluated. Outcomes: The mean distance of microscopic infiltration was 14.1 mm in depth and 14.3 mm circumferentially. The lesion completely regressed after the delivery of 40 Gy in 20 fractions over 4 weeks. The tumor did not recur over the next year. Conclusion: An aggressive disease course is rare for indolent CD30+ PC-ALCL, which has similar histopathological characteristics as indolent PC-ALCL. The radiotherapy strategy should be individualized with curative intent.