Open AccessAssociation between vitamin D receptor polymorphisms and acute pancreatitis
Author(s) -
Xiaofeng Li,
Xianghai Gan,
Junzuo Gong,
Tianyi Mou,
Hua Zhou,
Mengqin Li
Publication year - 2021
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000025508
Subject(s) - foki , taqi , medicine , meta analysis , calcitriol receptor , odds ratio , scopus , confidence interval , medline , pancreatitis , oncology , polymorphism (computer science) , vitamin d and neurology , genetics , genotype , gene , political science , law , biology
Background: Several studies have been performed to investigate the association between vitamin D receptor ( VDR ) gene polymorphism and acute pancreatitis, but the results are inconclusive. We conducted this meta-analysis for a precise estimation of the association between BsmI (rs1544410), ApaI (rs7975232), TaqI (rs731236), and FokI (rs2228570) polymorphisms and acute pancreatitis. Methods: Appropriate studies were retrieved by searching Web of Science, PubMed, Scopus, and Google scholar databases, until January 31, 2021. Two reviewers independently conducted data extraction and literature quality evaluation. Odds ratios and 95% confidence intervals were calculated to evaluate the strength of the association. All of the data were analyzed with Stata 16.0. Results: The results of this meta-analysis will be submitted to a peer-reviewed journal for publication. Conclusions: This meta-analysis will summarize the association between BsmI, ApaI, TaqI, and FokI polymorphisms and the risk of acute pancreatitis. Ethics and dissemination: Ethical approval was not required for this study. The systematic review will be published in a peer-reviewed journal, presented at conferences, and shared on social media platforms. OSF REGISTRATION NUMBER: DOI 10.17605/OSF.IO/83W7R.