Open AccessTraditional East Asian herbal medicines for the treatment of poststroke constipation
Author(s) -
Chul Jin,
Bo-Hyoung Jang,
Jin Pyeong Jeon,
Ye-Seul Lee,
Seung-Bo Yang,
Seungwon Kwon
Publication year - 2021
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000025503
Subject(s) - medicine , constipation , traditional medicine , stroke (engine) , meta analysis , alternative medicine , medline , systematic review , randomized controlled trial , intensive care medicine , clinical trial , publication bias , mechanical engineering , pathology , political science , law , engineering
Background: Post-stroke constipation is a major complication of stroke and increases the incidence of poor neurological outcomes and infectious complications and, therefore, warrants active and prompt treatment. In East Asian countries, several types of herbal medicines have been used for the treatment of post-stroke constipation because they are considered safer than existing pharmacotherapies. However, no systematic review has investigated the efficacy and safety of traditional East Asian herbal medicine in the treatment of post-stroke constipation. With this systematic review and meta-analysis, we aimed to evaluate the efficacy and safety of traditional East Asian herbal medicines for the treatment of post-stroke constipation. Methods and analysis: Eight electronic databases will be searched for relevant studies published from inception to April 2021. Only randomized controlled trials (RCTs) that assess the efficacy and safety of traditional East Asian herbal medicines for the treatment of post-stroke constipation will be included in this study. The methodological qualities, including the risk of bias, will be evaluated using the Cochrane risk of bias assessment tool. After screening the studies, a meta-analysis of the RCTs will be performed, if possible. Results: This study is expected to generate high-quality evidence of the efficacy and safety of herbal medicines to treat post-stroke constipation. Conclusion: Our systematic review will provide evidence to determine whether herbal medicines can be effective interventions for patients with post-stroke constipation. Ethics and dissemination: Ethical approval is not required, as this study was based on a review of published research. This review will be published in a peer-reviewed journal and disseminated electronically and in print. Trial registration number: Research registry reviewregistry1117