Open AccessEffects of programmed death ligand 1 on the prognosis of neuroblastoma
Author(s) -
Zelin Wu,
Feng-Gui Wei,
Yawei Zou
Publication year - 2021
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000024920
Subject(s) - medicine , hazard ratio , scopus , confidence interval , medline , meta analysis , neuroblastoma , web of science , oncology , biology , genetics , cell culture , political science , law
Background: Previous studies have investigated the prognostic role of programmed death ligand 1 (PD-L1) expression in patients with neuroblastoma, while the results are still controversial. Therefore, we conducted a meta-analysis to clarify the relationship between the expression of PD-L1 and the prognosis of neuroblastoma. Methods: Search electronic databases include PubMed, Cochrane, Embase, Scopus and Web of Science, and the search time is set to build the database until January 2021. Hazard ratio (HR) and 95% confidence interval (CI) were used to analyze the included results. Meta-analysis was performed using Stata 15.0 software. Results: This review will be disseminated in print by peer-review. Conclusion: The study will provide updated evidence for the evaluation of whether the expression of PD-L1 is associated with poor prognosis in patients with neuroblastoma. Ethics and dissemination: The private information from individuals will not be published. This systematic review also should not damage participants’ rights. Ethical approval is not available. The results may be published in a peer-reviewed journal or disseminated in relevant conferences OSF Registration number: DOI 10.17605/OSF.IO/FBCY6.