Open AccessEffectiveness and safety of Yufeng Ningxin for the treatment of essential hypertension
Author(s) -
Mingyan Huang,
Linzi Long,
Mi Deng,
Zikai Yu,
Hua Qu,
Ling Tan,
Yuxuan Peng,
Changgeng Fu
Publication year - 2021
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000024858
Subject(s) - medicine , cochrane library , randomized controlled trial , blood pressure , ambulatory blood pressure , essential hypertension , medline , clinical trial , meta analysis , adverse effect , intensive care medicine , protocol (science) , data extraction , ambulatory , alternative medicine , pathology , political science , law
Background: Essential hypertension is the primary cause of death and disability and it has become a major public health problem globally. Yufeng Ningxin (YFNX) is a commonly used Chinese patent medicine in treating essential hypertension. The objective of this protocol is to evaluate the effectiveness and safety of YFNX for the treatment of essential hypertension. Methods: Randomized controlled trials (RCTs) in relation to the effectiveness and safety of YFNX in the treatment of essential hypertension will be systematically searched and collected from the following databases: PubMed, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure, Wanfang Database, Chinese Biomedical Literature Database, and Chinese Scientific Journal Database from the database inception to January 1, 2021. The data screening and extraction will be carried out by 2 different reviewers. The quality of randomized controlled trials will be assessed based on the version 2 of the risk-of-bias tool for randomized trials (RoB 2) in the Cochrane Handbook. The reduction of systolic blood pressure (SBP) and diastolic blood pressure (DBP) will be served as the primary outcome. The secondary outcomes will include average SBP and average DBP during the day and the night measured by 24 hours ambulatory blood pressure monitoring, the clinical effectiveness rate, scores of traditional Chinese medicine syndrome, clinical symptoms, the quality of life and adverse events. Statistical analysis will be conducted with Review Manager 5.3 and STATA 14.0 software. Conclusion: This systematic review will provide strong evidence to assess the effectiveness and safety of YFNX in the treatment of essential hypertension. Trial registration number: INPLASY202110059.