Open AccessA systematic review and meta-analysis of integrated traditional Chinese medicine and Western medicine in treating glomerulosclerosis
Author(s) -
Yuetong Wang,
Rongqiang Zhang,
Shu-fei Wang,
Xiancheng Li,
Nan Zhang,
Ya-Feng Zhao,
Yu Wang,
Xiao Yu,
Kai Qu
Publication year - 2021
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000024799
Subject(s) - medicine , meta analysis , traditional medicine , medline , western medicine , alternative medicine , traditional chinese medicine , intensive care medicine , pathology , political science , law
Background: The combination of Traditional Chinese medicine and Western medicine (TCM+WM) has been widely used in the treatment of glomerulosclerosis, but the results are still controversial. This study will assess the clinical efficacy of TCM+WM for glomerulosclerosis and provide evidence-based medical data via meta-analysis. Method: The MEDLINE, EMBASE, PubMed, Cochrane Central Registry of Controlled Trials, and multiple Chinese databases (Wan Fang, CNKI, and VIP) were searched for randomized controlled trials (RCT) that compared the effects of WM and TCM+WM. Review Manager 5.3 software was used for the meta-analysis of selected studies, and appropriate tests were performed to determine the quality, heterogeneity and sensitivity of these studies. Results: Sixteen RCTs met the inclusion criteria and were selected for the analysis. Compared with the placebo or WM-treated glomerulosclerosis patients, TCM+WM intervention significantly improved renal function indices including 24-hour urine protein quantity (24 h U-Pro), serum creatinine (Scr), blood urea nitrogen (BUN), creatinine clearance (Ccr). In addition, the serum albumin (ALB), triglyceride (TG), and cholesterol (CHOL) levels were also significantly improved ( P < .05) in patients receiving the combination therapy. Finally, the combination of TCM+WM reduced the indices of glomerulosclerosis more effectively compared with WM alone. Conclusion: The combination of TCM+WM can significantly improve the renal function and prognosis of patients with glomerulosclerosis.