Open AccessEvaluation of contrast-enhanced ultrasound for activity of rheumatoid arthritis
Author(s) -
Yunpei Zhu,
Ping Sui,
Cong Wang,
Hui Wang,
Zhi-Hong Wen
Publication year - 2021
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000024417
Subject(s) - medicine , rheumatoid arthritis , cochrane library , contrast enhanced ultrasound , ultrasound , radiology , medical physics , medline , contrast (vision) , meta analysis , artificial intelligence , political science , computer science , law
Background: Contrast-enhanced ultrasound (CEUS) refers to a technique that uses contrast medium to strengthen the echo of backscatter, which can significantly improve the resolution, sensitivity and specificity of ultrasound diagnosis. As a quantitative imaging examination of blood flow signals, CEUS has allowed detection of synovial microvascularization in the joints of patients with rheumatoid arthritis (RA). However, the results of these studies have been contradictory. Therefore, the purpose of this study is to evaluate the value of CEUS in the activity of RA disease. Methods: We will search PubMed, Embase, Cochrane Library, and CNKI from their inception to the December 20, 2020, without restrictions of language and publication status. Two investigators will independently carry out searching literature records, scanning titles and abstracts, full texts, collecting data, and assessing risk of bias. This study will only include high quality clinical cohort or case control studies. Statistical analysis was performed by using the Review Manager version 5.3 and the STATA version 14.0 (Stata Corp, College Station, TX, USA) softwares. Results: This systematic review will determine the value of CEUS in RA activity scores. Conclusion: The results of this study will provide a useful basis for high-quality CEUS to evaluate RA activity score. Systematic review registration: INPLASY2020120125.