Open AccessClinical impact of 11C-Pittsburgh compound-B positron emission tomography in addition to magnetic resonance imaging and single-photon emission computed tomography on diagnosis of mild cognitive impairment to Alzheimer's disease
Author(s) -
Kazuhiro Kitajima,
Kazuo Abe,
Masanaka Takeda,
Hiroaki Yoshikawa,
Mana Ohigashi,
Keiko Osugi,
Hidenori Koyama,
Koichiro Yamakado
Publication year - 2021
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000023969
Subject(s) - pittsburgh compound b , medicine , progressive supranuclear palsy , dementia , magnetic resonance imaging , nuclear medicine , positron emission tomography , frontotemporal lobar degeneration , atrophy , vascular dementia , single photon emission computed tomography , frontotemporal dementia , radiology , disease
This study aimed to evaluated the clinical impact of adding [ 11 C] Pittsburgh compound-B ( 11 C-PiB) PET for clinical diagnosis of mild cognitive impairment (MCI) to Alzheimer's disease (AD) dementia. Twenty six (mean age 78.5 ± 5.18 years, 21 females) AD (n = 7), amnestic MCI (n = 12), non-amnestic MCI (n = 3), vascular dementia, progressive supranuclear palsy (PSP) with frontotemporal dementia (FTD), FTD (n = 1 each), and normal (n = 1) patients underwent 11 C-PiB-PET, MRI, and SPECT scanning. 11 C-PiB-PET was compared with MRI and SPECT for clinical impact. 11 C-PiB-PET showed positivity in 6, 9, and 0 of the AD, amnestic MCI, and non-amnestic MCI patients, respectively, and 0 of those with another disease. Parahippocampal atrophy at VSASD was observed in 5 AD patients, 6 amnestic and PiB-positive MCI patients, 1 amnestic and PiB-negative MCI patient, and 1 vascular dementia patient. Parietal lobe hypoperfusion in SPECT findings was observed in 6, 4, and 2 of those, respectively, as well as 1 each of non-amnestic MCI, vascular dementia, and normal cases. Sensitivity/specificity/accuracy for selecting PiB-positive patients among the 15 MCI patients for 11 C-PiB-PET were 100% (9/9)/100% (6/6)/100% (15/15), for VSRAD were 66.7% (6/9)/83.3% (5/6)/73.3% (11/15), and for SPECT were 44.4% (4/9)/50.0% (3/6)/46.7% (7/15), while those were 88.9% (8/9)/33.3% (2/6)/66.7% (10/15)/for combined VSRAD and SPECT. 11 C-PiB-PET accuracy was significantly higher than that of SPECT. 11 PiB-PET alone may be useful for selecting patients who will progress from MCI to AD in the future, although follow-up study is necessary to clarify the outcome of MCI patients.