Open AccessMultidisciplinary diagnosis and treatment of recurrent follicular dendritic cell sarcoma in abdomen
Author(s) -
Chang Qu,
Xiaodong Tian,
Yue Ma,
Xing Xie,
Mingyue Wang,
Yujun Dong,
Jixin Zhang,
Ping Liu,
Yinmo Yang
Publication year - 2020
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000023588
Subject(s) - medicine , paraneoplastic pemphigus , disease , follicular dendritic cells , abdomen , castleman disease , multidisciplinary team , pathology , dermatology , radiology , antibody , t cell , immunology , autoantibody , immune system , antigen presenting cell , nursing
Rationale: Follicular dendritic cell sarcoma (FDCS) is a rare malignant tumor derived from follicular dendritic cells, and is often associated with Castleman disease. Here we present a rare case of paraneoplastic pemphigus (PNP) with FDCS which required multidisciplinary approach for the diagnosis and treatment. Patient concerns: A 28-year-old Chinese female had FDCS recurrence, and primary clinical manifestation was PNP. Diagnoses: PNP with FDCS. Interventions: The patient received gamma globulin infusion, took anlotinib, and underwent plasma exchange therapy. Outcomes: The skin lesions recovered and there was no evidence of tumor recurrence. Lessons: The diagnosis and management of PNP with FDCS require close cooperation among surgeons, dermatologists, hematologists, otolaryngologists, oncologists, radiologists, pathologists, and respiratory doctors. The interesting clinical manifestations of this patient provide a multifaceted approach to the investigation of the interactions among FDCS, Castleman disease, and PNP.