Open AccessEfficacy of hydroxychloroquine in hand osteoarthritis
Author(s) -
Qiangqiang Li,
Yadong Xie,
Wei Liang,
Guanlin Yang,
Huaibin Zhang,
Yongping Wang
Publication year - 2020
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000023517
Subject(s) - medicine , hydroxychloroquine , osteoarthritis , medline , cochrane library , clinical trial , meta analysis , alternative medicine , physical therapy , randomized controlled trial , systematic review , grey literature , medical physics , intensive care medicine , pathology , covid-19 , disease , political science , infectious disease (medical specialty) , law
Background: Symptoms of hand osteoarthritis result in activity limitations and lower quality of life. Hydroxychloroquine, which has been used successfully in the treatment of many autoimmune diseases, can suppress inflammation and might also be beneficial in hand osteoarthritis. Methods: We plan to perform a systematic review and meta-analysis of randomized clinical trial to determine the symptom-modifying effect of hydroxychloroquine in hand osteoarthritis. We will search PubMed, EMBASE, Cochrane Library, and Web of Science using a comprehensive strategy. The related conference proceedings and reference lists of the included studies will also be checked to identify additional studies. Two reviewers will screen retrieved records, extract information and assess the risk of bias independently. Stata v15.1 software will be used to conduct data synthesis. Results: This study will be submitted to a peer-reviewed journal for publication. Conclusion: We hope it will provide a relatively comprehensive reference for clinical practice and future relevant clinical trials. INPLASY registration number: INPLASY2020110005