Open AccessProphylaxis of ibuprofen in acute mountain sickness
Author(s) -
Hai Yi,
Wang Kui-ying,
Xinyu Gan,
Li Li,
Qian Zhang,
Jiao Xiang,
Xiuwei Yuan,
Yugang Zhang,
Yonghua Wang
Publication year - 2020
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000023233
Subject(s) - medicine , ibuprofen , cochrane library , medline , meta analysis , web of science , intensive care medicine , emergency medicine , pharmacology , political science , law
Background: Acute mountain sickness (AMS) is the effect when people accessing high altitude in a short period of time. As a cyclooxygenase (COX) inhibitor, ibuprofen could alleviate the symptoms of AMS. However, whether it can prevent AMS or not is still controversial. It is necessary to perform a meta-analysis to evaluate the role of ibuprofen in AMS prophylaxis. Methods: PubMed, EMBASE, Medline, ISI Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI) will be searched for the relevant published studies that explored the value of ibuprofen in AMS prophylaxis from inception to October 2020. The data will be independently extracted by 2 researchers. Risk of bias will be evaluated based on Cochrane risk of bias assessment tool. Heterogeneity among the included studies will be evaluated by χ 2 and I 2 values. The meta-analysis was conducted by RevMan software version 5.3. Results: This study will evaluate the role of ibuprofen in AMS prophylaxis. Conclusion: This study will summarize the current evidence of ibuprofen in AMS prophylaxis, which could further guide the recommendation in prevention of AMS. Open Science Framework (OSF) registration number: October 8, 2020. osf.io/n3mjt.