Open AccessValue of 18F-FDG PET/CT in patients with hepatic metastatic carcinoma of unknown primary
Author(s) -
Yuekai Li,
Fengcai Li,
Xin Li,
Lili Qu,
Jikhyon Han
Publication year - 2020
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000023210
Subject(s) - medicine , positron emission tomography , nuclear medicine , standardized uptake value , primary tumor , radiology , retrospective cohort study , metastasis , pathology , cancer
Purpose This retrospective study aimed to investigate the clinical value of -deoxy-2-( 18 F)-fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) in detecting primary lesions of hepatic metastases. Methods A total of 124 patients with hepatic metastatic carcinoma of unknown primary underwent whole body 18 F-FDG PET/CT imaging. According to the final diagnoses for both primary sites and hepatic metastases that were confirmed either histopathologically or by clinical follow up, all patients were divided into 4 groups: a true positive group (TP, 95 cases), a false positive group (FP, 9), a true negative group (TN, 8) and a false negative group (FN, 12). Results The TP rate of primary lesions, detected by 18 F-FDG PET/CT, was 76.61%, the FP rate 7.26%, the TN rate 6.45% and the FN rate 9.68%. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 18 F-FDG PET/CT in the detection of primary tumors were 88.78%, 52.94%, 91.35%, 40%, and 83.06%, respectively. Accurate diagnosis groups (TP, TN) showed a significantly higher SUVmax (standard uptake maximum value) level than that in error diagnosis groups (FP, FN). The SUVmax between hepatic metastases and primary lesions had a positive correlation. The primary tumor sites of hepatic metastases were mainly located in the gastrointestinal organs and the lungs. Conclusions Whole body 18 F-FDG PET/CT imaging was sensitive for detecting primary sites/lesions with hepatic metastatases of unknown primary, especially when the SUVmax of hepatic metastases were greater than 4.7.