Open AccessA study of 18F-FLT positron emission tomography/computed tomography imaging in cases of prefibrotic/early primary myelofibrosis and essential thrombocythemia
Author(s) -
Mohamed A Yassin,
Sadek Nehmeh,
Abdulqadir J. Nashwan,
Samah Kohla,
Shehab Mohamed,
Omar M Ismail,
Ahmad Al Sabbagh,
Feryal Ibrahim,
Dina Sameh Soliman,
Lajos Szabados,
Hadi Fayad
Publication year - 2020
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000023088
Subject(s) - medicine , essential thrombocythemia , myelofibrosis , positron emission tomography , polycythemia vera , biopsy , bone marrow , janus kinase 2 , radiology , nuclear medicine , oncology , pathology , receptor
Abstract The objectives of this research project are to study in patients with primary myelofibrosis (PMF) and Essential Thrombocythemia (ET); (1) the uptake patterns of 18 FLT-PET (FLT-PET) and its value in diagnosing, staging, and treatment response monitoring of malignant hematopoiesis, (2) compare imaging findings from FLT-PET with bone marrow biopsy (standard of care), and (3) associate FLT-PET uptake patterns with genetic makeup such as JAK2 (Janus kinase 2), CALR (Calreticulin), MPL (myeloproliferative leukemia protein), Triple negative disease, and allele burden. This trial is registered in ClinicalTrials.gov with number NCT03116542. Protocol version: Mar 2017