Open AccessComparative efficacy and safety of injection therapies for knee osteoarthritis
Author(s) -
Ting Yu,
Shifan Yan,
Zhenhai Chi,
Daocheng Zhu,
Cheng Pan,
Haiyan Li,
Siyu Qin,
Genping Zhong,
Xilin Ouyang,
Rixin Chen,
Lin Jiao
Publication year - 2020
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000022943
Subject(s) - medicine , osteoarthritis , cochrane library , meta analysis , medline , randomized controlled trial , physical therapy , alternative medicine , pathology , political science , law
There are many injection methods for the treatment of knee osteoarthritis, but there is no comprehensive comparison, based on the fixed effect model. Methods: According to the retrieval strategy, we searched randomized controlled trials (RCTs) randomly from PubMed, the Cochrane Library, Embase, the China National Knowledge Infrastructure (CNKI), Wanfang Database from their inceptions to August 2020, and 2 members of us selected literatures and extracted data independently. Methodological quality was assessed by using the Cochrane bias risk tool, and meta-analysis was performed by using the Stat.14.0. Results: This study will evaluate the effectiveness and safety of different injectable drugs for the treatment of knee osteoarthritis and rank the efficacies of drugs, then to determine the optimal treatment. Conclusion: This study will provide evidence for the choice of injection therapy for knee osteoarthritis. INPLASY registration number: INPLASY202080099.