Open AccessOccult olfactory neuroblastoma presenting with multiple bone metastases: a case report
Author(s) -
Qi Zhou,
Zijian Li,
Bei Liu,
Long Zhao,
Baohong Tian,
Lina Wang,
Yuandi Xi
Publication year - 2020
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000022630
Subject(s) - medicine , occult , nasal cavity , radiology , magnetic resonance imaging , biopsy , multiple myeloma , bone marrow , primary tumor , positron emission tomography , neuroblastoma , esthesioneuroblastoma , primary bone , metastasis , surgery , pathology , cancer , genetics , biology , cell culture , alternative medicine
Rationable: Olfactory neuroblastoma (ONB) is a rare malignant tumor of the nasal cavity, the primary local symptoms are usually inconspicuous. Patients are often admitted to various specialties based on different primary symptoms, which may result in delayed diagnosis and even a misdiagnosis. Patient concerns: Here we report a case of ONB that presented initially as multiple ostealgia without any local symptoms of the tumor and primarily misdiagnosed as multiple myeloma. The patient was a 47-year-old female with bone pain at multiple sites. The initial diagnosis was considered as multiple myeloma. However, the morphologic examination of bone marrow suggested that the tumor cells originated from the nervous tissues. After the positron emission computed tomography scan, the primary lesion in the nasal cavity was located, and a biopsy was performed. Diagnosis: The final diagnosis of ONB was confirmed by histopathological tests. Interventions: The patient was treated with metronomic chemotherapy. Outcomes: The symptoms of bone pain were significantly relieved 3 months later. The emission computed tomography scan of the whole body bones and the magnetic resonance imaging of the head showed that the tumor size did not change significantly and proved a progression-free of the disease. Lessons: It is a reasonable strategy to identify the original latent tumor by a prompt positron emission computed tomography scan when the primary diagnosis indicates a metastatic disease, especially for the occult malignancies like ONB.