Open AccessPrimary pure large cell neuroendocrine carcinoma of the ovary
Author(s) -
Ping Xue,
Hongjing Wang
Publication year - 2020
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000022474
Subject(s) - medicine , exploratory laparotomy , histopathology , ovary , clear cell carcinoma , chemotherapy , pathology , laparotomy , ovarian cancer , ovarian carcinoma , oncology , carcinoma , radiology , cancer , surgery
Ovarian large cell neuroendocrine carcinoma (LCNEC), or ovarian non-small cell neuroendocrine carcinoma, which is a newly described tumour in the classification of primary ovarian neoplasms by the World Health Organization, is a rare entity that is frequently associated with a surface epithelial and germ cell neoplasm component. Few cases have been reported in the literature, and only 18 primary pure ovarian LCNEC cases have been reported so far, including our 1 case. Ovarian LCNEC is a highly aggressive tumor with a poor prognosis even at an early stage. Patient concerns: We report a case of a 55-year-old postmenopausal woman who complained of abdominal pain. CT examination revealed a mass in the right adnexial region and CA125 level was elevated. Diagnosis: She underwent a exploratory laparotomy, and diagnosed as LCNEC histopathologically. Interventions: Cytoreductive surgery was administered to the patient, and had accepted 5 cycles of chemotherapy consisting of paclitaxel and cisplatin. Outcomes: Follow-up for 12 months showed no clinical or radiological evidence of disease recurrence. Conclusion: This case is 1 of the ovarian LCNEC which is a rare and extremely malignant tumor. Diagnosis requires histopathology and immunohistochemistry. The treatment includes primary cytoreductive surgery followed by chemotherapy.