Open AccessEfficacy and safety of total glucosides of paeony for rheumatoid arthritis
Author(s) -
Ce Tang,
Ye Lianghong,
Zhipeng Hu,
Wenxiang Wang,
Tingting Kuang,
Gang Fan,
Xiuhua Li,
Maoyi Yang
Publication year - 2020
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000022224
Subject(s) - medicine , funnel plot , rheumatoid arthritis , publication bias , erythrocyte sedimentation rate , meta analysis , inclusion and exclusion criteria , adverse effect , clinical trial , rheumatoid factor , medline , alternative medicine , physical therapy , intensive care medicine , pathology , political science , law
Background: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by erosion of joints and surrounding tissues. RA not only causes the decline of patients’ physical function and quality of life, but also brings huge economic burden to patients’ families and society. Total glucosides of paeony (TGP) is commonly used in treating RA in China. At present, there are many clinical reports about this medicine, but these reports have their own flaws. Therefore, there is an urgent need for systematic review and meta-analysis of the existing clinical evidence. Methods and analysis: Literature search will be carried out in 6 databases, and the literatures will be screened according to the inclusion and exclusion criteria. The clinical effective rate will be taken as primary outcome. Serum rheumatoid factor, C-reactive protein, erythrocyte sedimentation rate, Western Ontario and McMaster before and after treatment and adverse effects will be secondary outcomes. The heterogeneity of the study will be examined by χ 2 and I 2 test. To identify the source of heterogeneity, subgroup analysis will be carried out. The sensitivity test will be conducted investigate the stability of results. Funnel plot and Egger test will be used to evaluate publication bias. Finally, the quality of evidence will be summarized. Results: The results will be published in peer-reviewed journals. Conclusions: This study will systematically evaluate the efficacy of TGP in the treatment of RA. The results of this study can better guide clinical practice. OSF registration number: DOI 10.17605/OSF.IO/85QVF.