Open AccessPrimary gastric squamous cell carcinoma presenting as a large submucosal mass
Author(s) -
Lei Gao,
Xiaolong Tang,
Hui Qü,
Qin He,
Guangbin Sun,
Jianguo Shi,
Jianhong Ye,
Yong Liang
Publication year - 2020
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000022125
Subject(s) - medicine , stromal tumor , pathological , stomach , gist , gastrectomy , biopsy , endoscopic mucosal resection , gastroenterology , endoscopy , surgery , stromal cell , radiology , cancer
Rationale: Primary gastric squamous cell carcinoma (SCC) is rarely encountered clinically. SCC, which presents as a submucosal tumor, is even rarer. Without the support of pathological evidence, it is difficult to make a correct preoperative diagnosis. Due to limited clinical data, the pathogenesis and treatment of gastric SCC remain unclear. Patient concerns: A 69-year-old man was admitted to our hospital with unexplained weight loss. Endoscopy revealed a submucosal mass without any ulcer on its surface located on the body of the stomach. The results of 2 gastroscopic mucosal biopsies were chronic inflammation. Diagnoses: The clinical diagnosis by computed tomography (CT) and gastroscopy was gastrointestinal stromal tumor (GIST) preoperatively. The postoperative pathological examination demonstrated this tumor as moderately differentiated SCC. Interventions: Total gastrectomy, distal pancreatectomy, and splenectomy were performed. Outcomes: The patient was discharged 7 days after the surgery without any complications. The follow-up CT scan showed no evidence of metastatic disease 6 months after surgery. Lessons: Large primary gastric SCC could present as a submucosal mass. Gastroscopic mucosal biopsy may not be able to get tumor tissue due to inflammatory reaction.