Open AccessChryseobacterium arthrosphaerae ventriculitis
Author(s) -
Jae Hyoung Im,
Donghwi Kim,
Jin Ju Kim,
Eun Young Kim,
Young Kyoung Park,
Hea Yoon Kwon,
Moon-Hyun Chung,
Ji Hyeon Baek,
Jin Soo Lee
Publication year - 2020
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000021751
Subject(s) - medicine , ventriculitis , chryseobacterium , surgery , meningitis , 16s ribosomal rna , biology , bacteria , genetics
Chryseobacterium arthrosphaerae is a gram-negative bacteria, known for its intrinsic multidrug resistance, which can lead to treatment difficulties. Patient concerns: A 56-year-old male had an indwelling external ventricular drainage catheter for 6 months and had been frequently treated with antibiotics for nosocomial infections. He showed cerebrospinal fluid pleocytosis and an abrupt fever during hospitalization. Diagnosis: He was diagnosed as a ventriculitis caused by Chryseobacterium arthrosphaerae (C arthrosphaerae) . Intervention: Initially, we used ciprofloxacin as the backbone in combination with minocycline (and rifampin). However, fever and pleocytosis persisted, and improvement was slow. We then switched the minocycline and rifampin regiment to trimethoprim/sulfamethoxazole. Following this switch of antibiotics, the patient's pleocytosis rapidly improved, allowing the replacement of his external ventricular drainage catheters. C arthrospharae was no longer growing in cerebrospinal fluid and he was recovered from ventriculitis. Outcomes: The patient remains alive without any incidence of C arthrosphaerae recurrence. Conclusion: We propose trimethoprim/sulfamethoxazole alone or in combination with ciprofloxacin to be good candidates for the treatment of ventriculitis by C arthrosphaerae .