Open AccessSocial cognition in multiple sclerosis and its subtypes
Author(s) -
XiaoGuang Lin,
Xueling Zhang,
QinQin Liu,
PanWen Zhao,
JianGuo Zhong,
PingLei Pan,
Gendi Wang,
ZhongQuan Yi
Publication year - 2020
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000021750
Subject(s) - cognition , medicine , neuropsychology , social cognition , multiple sclerosis , social cognitive theory , systematic review , meta analysis , medline , clinical psychology , psychiatry , developmental psychology , psychology , pathology , political science , law
Abstract Background: Multiple sclerosis (MS) is an inflammatory and degenerative neurological disorder of the central nervous system. Cognitive impairment is frequent in MS patients, which not only includes deficits in abilities assessed by traditional neuropsychological batteries, but also often features impairments in social cognition (including theory of mind and facial emotion recognition). Recently, numerous studies have assessed social cognition performance in MS. However, there have been inconsistent findings. Besides, it is not clear how social cognitive abilities are affected in MS subtypes. The aim of this study is to conduct a meta-analysis to characterize social cognition performance in MS and its subtypes (clinically isolated syndrome, relapsing-remitting MS, progressive primary MS, and secondary progressive MS). Methods: Literature sources will be divided into 2 sections: electronic sources and manual sources. A systematic literature search will be performed for eligible studies published up to June 10, 2020 in 3 international databases (Embase, PubMed, and Web of Science). In addition, manual sources will be searched, such as the references of all included studies. Two researchers will independently conduct the work such as article retrieval, screening, quality evaluation, data collection. Meta-analysis will be conducted using Stata 15.0 software. Results: The results of this study will be published in a peer-reviewed journal. Conclusions: This meta-analysis will provide a high-quality synthesis from existing evidence for social cognition performance in MS and its subtypes. PROSPERO registration number: INPLASY202070028.