Open AccessEfficacy of oral Vitamin D supplementation in reducing body mass index and lipid profile in adolescents and young adults in Colombia
Author(s) -
Norma C. Serrano,
Sandra L. Romero,
Diana Paola Suárez Suárez,
Lyda Z. Rojas,
Edna Magaly Gamboa-Delgado,
Mario Forero,
Elizabeth Guío,
Doris Cristina Quintero-Lesmes
Publication year - 2020
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000021722
Subject(s) - medicine , body mass index , vitamin d and neurology , context (archaeology) , population , randomized controlled trial , metabolic syndrome , lipid profile , physical therapy , young adult , waist , gerontology , physiology , environmental health , cholesterol , obesity , paleontology , biology
Background: In recent years, the role of vitamin D (VD) as a protective factor in cardiovascular disease has been recognized. Thus, there is a need to study the effect of vitamin D supplementation in the control of different cardiovascular risk factors and metabolic syndrome, especially in young populations where few studies have been conducted. Methods: Pilot study of a randomized, parallel two-arm, triple-blind clinical controlled trial in 150 adolescents and young adults in the city of Bucaramanga-Colombia. The intervention group will receive 1000 IU of VD and the control group 200 IU of VD daily for 15 weeks. The main outcomes are: serum calcifediol levels (25(OH) D), body mass index and lipid profile; secondary outcomes are complementary to the previous ones (skin folds, waist-hip ratio). Other variables will be analyzed such as assessment of dietary intake, physical activity, sun exposure, cigarette and tobacco consumption and compliance with VD supplementation. Discussion: This study is innovative since there is little evidence from clinical trials in adolescents and young adults; similar studies are not known in our context. The results of this study may facilitate the recommendation of oral vitamin D supplementation in the population of interest. In addition, it is a low-cost and easy-to-apply intervention that could contribute to the formulation and implementation of health policies. Trial registration: NCT04377386