Open AccessAnkylosing spondylitis complicating Turner syndrome
Author(s) -
Fangfei Chen,
Xue-Han Zhang,
Yang Jiao
Publication year - 2020
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000021636
Subject(s) - medicine , ankylosing spondylitis , spondylitis , turner's syndrome , turner syndrome , pediatrics , surgery
Rationale: Turner syndrome (TS) is an anomaly caused by loss of part of or all the X chromosomes. Ankylosing spondylitis (AS) is an HLA-B27-associated autoimmune disease with a male predominance. It is widely accepted that TS patients are at higher risk of autoimmune diseases, but AS in TS patients has only rarely been reported. Patient concerns: A 13-year-old TS patient presented with intermittent pain in both hip joints, and a 27-year-old TS patient presented with thoracic kyphosis and a history of AS. Diagnoses: Both patients were diagnosed with AS according to their symptoms, laboratory results, and imaging. Interventions: The first patient was treated with tocilizumab for 8 months, whereas the second patient was treated with diclofenac initially with subsequent surgery for thoracic kyphosis. Outcomes: Treatment relieved the symptoms of both patients and laboratory parameters improved. Lessons: Even though AS has a male predominance, clinicians should be aware that AS and TS may co-exist and that the clinical features are atypical in TS patients with AS.