Open AccessEffects of gut microbiome-targeted therapies on cardiometabolic outcomes in children and adolescents
Author(s) -
Liyuan Yan,
Minghan Wang,
Jingjing Chen,
Xin Zhao,
Haipeng Wang
Publication year - 2020
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000021612
Subject(s) - medicine , microbiome , gut microbiome , data extraction , gut flora , medline , disease , protocol (science) , clinical trial , meta analysis , bioinformatics , systematic review , clinical study design , intensive care medicine , alternative medicine , immunology , pathology , political science , law , biology
Background: Emerging evidence indicates the role of gut microbiota in the development of cardiovascular diseases. Thus, gut microbiota is increasingly recognized as a potential therapeutic target of cardiovascular disease. However, the effects of gut microbiome-targeted therapies on cardiometabolic outcomes in children and adolescents remain unclear. Methods: We plan to perform a systematic search from PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and Web of Science. Two authors will independently select the relevant studies and extract data according to a previously defined data extraction sheet. We will use the Stata 14.0 statistical software and RevMan V.5.3 software to conduct data analyses. Results and conclusion: The results of this study will be published in a peer-reviewed journal and provide more evidence for the application of gut microbiome-targeted therapies in children and adolescents for the intervention of cardiovascular risk factors in clinical practice. Protocol registration number: INPLASY202060050.