Open AccessEffect of butylphthalide on new cerebral microbleeds in patients with acute ischemic stroke
Author(s) -
Yuanhua Ding,
Zhiqun Gu,
Tingting Zhai,
Wenjuan Wang,
Yanrong Zhang,
Can Wei,
Yan Liu,
Jingyang Niu
Publication year - 2020
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000021594
Subject(s) - medicine , magnetic resonance imaging , placebo , stroke (engine) , ischemic stroke , clinical trial , radiology , ischemia , pathology , alternative medicine , engineering , mechanical engineering
Background: To evaluate the effect of dl-3-N-butylphthalide (NBP) on new cerebral microbleeds (CMBs) in patients with acute ischemic stroke (AIS). Methods: We will prospectively enroll patients with AIS admitted to the stroke center of Jingjiang People's Hospital. Qualified participants will be randomly assigned to either the NBP group (NBP injection) or the control group (NBP injection placebo) in a ratio of 1:1. Patients will complete the brain magnetic resonance imaging within 48 hours and 14 days after stroke onset to observe the CMBs through susceptibility weighted imaging, and evaluate whether the use of NBP will affect the new CMBs in AIS patients. SPSS 20.0 will be used for statistical analyses. Result: We will provide practical and targeted results assessing the safety of NBP for AIS patients, to provide reference for clinical use of NBP. Conclusion: The stronger evidence about the effect of NBP on new CMBs in AIS patients will be provided for clinicians.