Open AccessEffects of Yangxinshi tablet on exercise tolerance in patients with coronary heart disease
Author(s) -
Sisi Zhang,
Congying Liang,
Yang Yang,
Zhijia Zhao,
Jiaojiao Li,
Xiaoping Meng
Publication year - 2020
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000021485
Subject(s) - medicine , physical therapy , placebo , randomized controlled trial , coronary heart disease , adverse effect , quality of life (healthcare) , rehabilitation , clinical trial , exercise intolerance , traditional chinese medicine , heart failure , alternative medicine , nursing , pathology
Background: Exercise intolerance is very common in patients with coronary heart disease (CHD). Although some researches confirming the validation of traditional Chinese medicine (TCM) on CHD treatment, the effect of TCM on improving the exercise tolerance of patients with CHD remains unclear so far. Our trial is to investigate whether the Yangxinshi (YXS) tablet can improve exercise tolerance as well as the quality of life among CHD patients. Methods: It is a randomized, double-blind, placebo-controlled, multi-center trial. A total of 90 patients with CHD from 3 hospitals in China will be enrolled and randomly assigned to one of 2 groups: YXS group, N = 45; placebo group, N = 45. The 2 groups will simultaneously receive standardized western medicine and exercise-based cardiac rehabilitation program for 12 weeks. The primary outcome measure is the exercise capacity, which will be evaluated by the cardiopulmonary exercise test and 6-minute walking test. The 2nd outcomes include symptom improvement, psychologic issues, laboratory tests, side effects, and adverse events. Discussion: To our knowledge, it is the 1st randomized controlled trial to evaluate the effect of TCM YXS tablet on exercise tolerance in patients with CHD. The results will provide more evidence for future studies in this area. Trial registration: This study protocol was registered in Research Registry (researchregistry5752).