Open AccessTreatment of high risk human papillomavirus infection in low grade cervical squamous intraepithelial lesion with mild local thermotherapy
Author(s) -
Yang Yang,
Lan Zhang,
Ruiqun Qi,
Wei Huo,
Xiaodong Li,
Xin Wu,
HongDuo Chen,
XingHua Gao
Publication year - 2020
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000021005
Subject(s) - medicine , cervical intraepithelial neoplasia , squamous intraepithelial lesion , cervix , lesion , cytology , human papillomavirus , hyperthermia , hpv infection , colposcopy , gynecology , gastroenterology , pathology , cervical cancer , cancer
Mild local hyperthermia at 44°C has been proven efficacious in the treatment of cutaneous warts induced by human papillomavirus (HPV), while its effect on cervical intraepithelial neoplasia (CIN) caused by high risk type of HPVs has not been reported. Patient concerns: Three patients with low grade CIN and positive high risk HPV types (HPV 16, 31, 52, 56, 58) are reported in this study . Diagnosis: The diagnosis was based on identification of HPV types and abnormal cytological findings. Interventions: The 3 patients were treated with local hyperthermia from ceramic heating (surface temperature, 44°C) to cervix. The treatment was delivered once a day for 3 consecutive days, plus two similar treatments 10 ± 3 days later, with each session lasting 30 minutes. HPV and cytology test were performed 3 months thereafter. Outcomes: All the 3 patients recovered to normal cytological findings. Two of the patients were negative for HPV, the remaining patient with pre-treatment HPV 56 and 58 positivity changed to HPV58 positive alone. Conclusion: This pilot observation inspires that mild local hyperthermia be recommended as a new method in the treatment of CIN patients with persistent HPV infection, once validated by qualified RCT.