Open AccessDose–response of rPMS for upper Limb hemiparesis after stroke
Author(s) -
Satoki Kinoshita,
K Ikeda,
Shinji Yasuno,
Sho Takahashi,
Naoki Yamada,
Yumi Okuyama,
Nozomu Sasaki,
Takuya Hada,
Chiaki Kuriyama,
Shin Suzuki,
Midori Hama,
Naoto Ozaki,
Satoshi Watanabe,
Masahiro Abo
Publication year - 2020
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000020752
Subject(s) - medicine , hemiparesis , stroke (engine) , upper limb , spasticity , physical therapy , rehabilitation , randomized controlled trial , physical medicine and rehabilitation , activities of daily living , clinical endpoint , occupational therapy , surgery , angiography , mechanical engineering , engineering
Abstract Introduction: Repetitive peripheral magnetic stimulation (rPMS) therapy is an innovative and minimally invasive neurorehabilitative technique and has been shown to facilitate neural plasticity. However, there is at present no research that clarifies the dose–response of rPMS therapy on the recovery of upper limb hemiparesis after stroke. This trial aims to clarify the dose–response of rPMS therapy combined with intensive occupational therapy (OT) for chronic stroke patients with moderate to severe upper limb hemiparesis. Methods and analysis: This multicenter, prospective, assessor-blinded, randomized controlled study with 3 parallel groups will be conducted from January 20, 2020 to September 30, 2022. Fifty patients will be randomly assigned in a ratio of 1:2:2 to the control group, the group receiving daily 2400 pulses of rPMS, or the group receiving daily 4800 pulses of rPMS, respectively. From the day after admission (Day 1), rPMS therapy and intensive OT will be initiated. The primary outcome is the change in the motor function of the affected upper extremity (Fugl-Meyer Assessment) between the time of admission (Day 0) and the day after 2 weeks of treatment (Day 14). Secondary outcomes will include the changes in spasticity, active range of motion, motor evoked potential, and activity of daily living. Ethics and dissemination: The study was approved by the Jikei University Certified Review Board for all institutions (reference number: JKI19–020). Results of the primary and secondary outcomes will be published in a peer-reviewed journal and presented at international congresses. The results will also be disseminated to patients. Trial registration number: jRCTs032190191.