Open AccessEfficacy of intrathecal baclofen bolus on neuropathic pain in patients with spinal cord injury
Author(s) -
Shoufeng Wang,
Zeng-Mian Wang,
Weidong Song,
Zhao-Chen Tang,
Ying Chai
Publication year - 2020
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000020484
Subject(s) - medicine , funnel plot , cochrane library , spasticity , medline , publication bias , neuropathic pain , meta analysis , spinal cord injury , adverse effect , clinical trial , physical therapy , emergency medicine , anesthesia , spinal cord , psychiatry , political science , law
Background: This study will explore the efficacy and safety of intrathecal baclofen bolus (IBB) on neuropathic pain (NPP) in patients with spinal cord injury (SCI). Methods: All potential literatures of IBB on NPP in patients with SCI will be searched from the following electronic databases from inauguration to the January 31, 2020: PUBMED, EMBASE, Cochrane Library, Web of Science, Chinese Scientific Journal Database Information, WANGFANG, and China National Knowledge Infrastructure. In addition, we will search other sources, such as dissertations and reference lists of included trials. There are no restrictions of language and publication status in searching all literature sources. The quality of each eligible trial will be assessed using Cochrane risk of bias tool, and publication bias will be checked using a funnel plot and Egger test. Statistical analysis will be conducted using RevMan 5.3 software. Results: This study will scrutinize the efficacy and safety of IBB on NPP in patients with SCI through pain intensity of NPP, spasticity, walking ability, health-related quality of life, duration of stay at hospital (days), incidence of adverse event, and mortality rate. Conclusions: The findings of this study will present helpful evidence to judge whether IBB is effective on NPP in patients with SCI or not. Study registration number: INPLASY202040192.