Open AccessRecurrent meningococcal meningitis with complement 6 (C6) deficiency
Author(s) -
JaeYoung Bae,
Ahrong Ham,
Hee Jung Choi,
Chung Jong Kim
Publication year - 2020
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000020362
Subject(s) - medicine , meningococcal disease , meningitis , meningococcal meningitis , ceftriaxone , meningococcal vaccine , pediatrics , neisseria meningitidis , bacterial meningitis , immunology , intensive care medicine , antibiotics , antigen , immunization , biology , bacteria , microbiology and biotechnology , genetics
Rationale: Late complement deficiency increases susceptibility to meningococcal disease and recurrent infections. In Korea, 5 case reports have described meningococcal disease with complement deficiency. However, C6 deficiency has not been described previously. Patient concerns: A 21-year-old police trainee presented with recurrent meningococcal meningitis. He was housed in communal living quarters until 20 days before the initial symptom onset. Diagnosis: He was diagnosed with meningococcal meningitis with C6 deficiency. Interventions: He was treated with intravenous ceftriaxone. An additional dose of quadrivalent meningococcal conjugate vaccine was administered after discharge. Outcomes: He was discharged without complications. Lessons: Screening for complement deficiency is necessary in patients with a history of recurrent meningococcal infections to provide appropriate care and prevent recurrent infections.