Open AccessGastric adenocarcinoma of the fundic gland type
Author(s) -
Xue Fan,
Xuesong Yang,
Peng Bai,
Yanzhi Ren,
Lei Zhang,
Xin Li,
Li Wang,
Yan Wang,
Yiming Ding,
Ranran Zeng,
Xiang-Chun Lin
Publication year - 2020
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000020361
Subject(s) - medicine , esophagogastroduodenoscopy , curvatures of the stomach , adenocarcinoma , pathology , hyperplasia , pathological , biopsy , stomach , lesion , gastroenterology , endoscopy , cancer
Gastric adenocarcinoma of the fundic gland type (GA-FG) is a newly described entity that is characterized by well-differentiated neoplasm with unclear etiopathogenesis. Patient concerns: A 60-year-old Chinese man was referred to our hospital for abdominal distension. Diagnosis: Esophagogastroduodenoscopy (EGD) showed a depressed lesion found using in the greater curvature of the stomach. The pathological diagnosis of the biopsy specimens indicated that the tumor was GA-FG (chief cell predominant type, GA-FG-CCP). Interventions: Endoscopic submucosal dissection (ESD) was performed. The histopathological examination of the ESD specimen revealed gastric hyperplasia of the fundic gland type around the adenocarcinoma cells. Outcomes: The surgical outcomes were good. The EGD showed a scar with no recurrence, and no symptoms were observed 1 year postoperatively during the follow-up. Conclusion: We present a rare case of a depressed lesion with a pathogenic expression suggesting gastric hyperplasia of the fundic gland type around the adenocarcinoma cells. Considering the origin of oxyntic mucosa, we consider that it may develop into GA-FG. To understand this issue better, similar cases should be monitored in the future.