Open AccessMultiple versus single doses of dexamethasone in total hip arthroplasty
Author(s) -
Bangjian Zhang,
Shaoqiong Sun,
Bo Sheng
Publication year - 2020
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000020147
Subject(s) - medicine , dexamethasone , nausea , regimen , anesthesia , visual analogue scale , range of motion , vomiting , arthroplasty , surgery , randomized controlled trial , informed consent , postoperative nausea and vomiting , institutional review board , alternative medicine , pathology
Background: Reduction of post-operative pain, nausea, and vomiting in patients undergoing total hip arthroplasty (THA) may facilitate earlier discharge from hospital and reduce healthcare costs. The recommended dose regimen of dexamethasone in THA has not been determined. The purpose of this study was performed to compare the efficiency of multiple versus single doses of dexamethasone for early postoperative pain treatment after THA. Methods: This study was a randomized controlled trial which conducted in our hospital. Informed consent for participation in this trial was obtained from each patient before surgery. Two hundred patients undergoing THA received 1 dose of intravenous dexamethasone and 1 dose of normal saline (Group A), or 2 doses of intravenous dexamethasone (Group B). The primary outcome was visual analog scale pain scores in the immediate postoperative period. Secondary outcomes included postoperative opioid use, length of hospital stay, activity level during physical therapy, and hip range of motion. Results: This clinical trial might provide some insights to estimate the safety of dexamethasone. Trial registration: This study protocol was registered in Research Registry (researchregistry5460).