Open AccessPrimary hepatoid carcinoma of the ovary
Author(s) -
Won-Ku Choi,
DongHyu Cho,
Chang-Yeol Yim,
Na-Ri Lee
Publication year - 2020
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000020051
Subject(s) - medicine , chemotherapy , ovary , abdominal pain , bloating , carcinoma , endometriosis , carboplatin , surgery , histopathology , gastroenterology , pathology , cisplatin
Hepatoid carcinoma of the ovary (HCO) is a rare disease that originates from the ovarian surface epithelium. It is histologically characterized as hepatocellular carcinoma (HCC) with a hepatocyte-rich granular cytoplasm. Patient concerns: A 65-year-old female patient was admitted with complaints of indigestion, abdominal bloating, and pain. Diagnosis: The patient showed an elevated level of serum alpha-fetoprotein (AFP) with abdominal bloating and pain. After surgery and histopathology analysis, she was finally diagnosed with HCO, Figo stage IC. Interventions: After cytoreductive surgery, she underwent adjuvant chemotherapy with carboplatin and paclitaxel. Although the disease was diagnosed at an early stage, it recurred 6 months after completion of adjuvant chemotherapy. Elevation of serum AFP level and removal of a mass from the lumbar vertebra confirmed the recurrence of this disease. Subsequently, the patient underwent radiation therapy and palliative chemotherapy. Outcomes: She died 31 months after the diagnosis due to disease progression. Conclusion: The aggressive nature of HCO was clearly observed in this case despite early diagnosis and treatment. Further studies are needed to understand the proper treatment and prognostic factors of HCO.