Open AccessA prospective observational study to investigate the correlation analysis between neonatal hyperbilirubinemia and deafness gene
Author(s) -
Xiaohui Wu,
Xingqiang Gao,
Gang Li,
Qiuxue Cao,
Yufeng Guo,
Hongsheng Deng,
Yun Zheng
Publication year - 2020
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000019774
Subject(s) - medicine , observational study , pediatrics , audiometry , prospective cohort study , hearing loss , audiology
There are many studies on the relationship between serum levels of hyperbilirubinemia and hearing impairment. However, the mechanism of hyperbilirubinemia on auditory impairment is not clear. Methods and analysis: A total of 1000 children with hyperbilirubinemia who are mainly indirectly elevated bilirubin in the full-term neonatal ward of Xiamen Children's Hospital from March 2020 to September 2020 will be enrolled. Using second-generation high-throughput sequencing technology, 127 deaf-related genes were sequenced from the collected samples. At the same time, physical audiometry was performed on the selected persons and audiometry data were recorded. Discussion: In this study, we will combine gene sequencing with clinical indications of hyperbilirubinemia to find the loci suitable for high-frequency pathogenic deafness related to hyperbilirubinemia, so as to provide early guidance for deafness gene screening in children with hyperbilirubinemia. Trial registration: Chinese Clinical trial registry: ChiCTR2000030075.