Open AccessEffect of changes in serum levels of endogenous hydrogen sulfide on fracture healing
Author(s) -
Feng Liao,
Zongdong Zhu,
Chengwei Xiao,
Bo Tan,
Xiaoming Tang,
Dan Wei,
Jian Yuan,
Xuemei Xiang,
Jiang Hu
Publication year - 2020
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000019684
Subject(s) - medicine , bone healing , creatinine , orthopedic surgery , ethics committee , fracture treatment , urinary system , informed consent , prospective cohort study , surgery , alternative medicine , pathology , public administration , political science
Background: Fracture is a common disease; many factors affect fracture healing. Recent studies have confirmed that hydrogen sulfide (H 2 S) plays an essential role in bone formation, but most of these studies are drawing conclusions based on animal experiment; whether H 2 S could promote fracture healing in patients is still unclear. We aim to investigate the change of serum H 2 S in fracture patients, and analyze its effort on fracture healing. Methods: This is a single-center, prospective cohort study. Patients with spinal or limb fracture will be recruited. Patient's serum and urine will be collected at baseline for examination (serum H 2 S, β-CTX, OC, PINP, 25-OH-VitD 3 , S-CTX, urinary calcium, and urinary creatinine). All patients will be followed-up for 24 months in outpatients settings, the image of X-ray or CT will be reviewed and fracture healing will be judged by 2 experienced orthopedic physicians. The difference in serum parameters especially H 2 S will be compared between patients with fracture healed within 9 months and those with fracture unhealed at 9 months. Discussion: Results of the trial could provide insight into influence of H 2 S on fracture healing. Ethics and dissemination: The study was approved by the ethics committee of School of Medicine UESTC & Sichuan Provincial People's Hospital Ethics Committee. All the participants will be asked to provide written informed consent before data collection. The findings of the study will be published in peer-reviewed journals and will be presented at national or international conferences.