Open AccessThe association between HHEX single-nucleotide polymorphism rs5015480 and gestational diabetes mellitus
Author(s) -
Xingjie Wang,
Yuanlin Ding,
Xinshan Zhang,
Jiawei Rao,
Haibin Yu,
Haiyan Pan
Publication year - 2020
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000019478
Subject(s) - medicine , odds ratio , gestational diabetes , genotype , confidence interval , meta analysis , gynecology , genetics , pregnancy , biology , gestation , gene
Objective: To evaluate the association between the rs5015480 single-nucleotide polymorphism of hematopoietically expressed homeobox ( HHEX ) and gestational diabetes mellitus (GDM) via meta-analysis. Methods: A comprehensive electronic search was performed of the PubMed, Springer, Science Direct, China National Knowledge Infrastructure (CNKI), Wanfang, and VIP databases for studies worldwide on the relationship between HHEX rs5015480 and GDM published up to July 2019. Rigorous inclusion and exclusion criteria were developed, and the quality of studies was assessed using the Newcastle–Ottawa scale, followed by heterogeneity evaluation using the Q test and I 2 statistic and data pooling. A meta-analysis was then performed on the included studies using RevMan 5.3. Results: A total of 4 eligible case–control studies were included, involving a total of 1651 patients and 3513 controls. The meta-analysis showed the following odds ratios: C allele vs T allele, 1.24 (95% confidence interval [CI]: 1.12–1.38); CC genotype vs TT genotype, 1.65 (95% CI: 1.26–2.17); CC genotype vs CT genotype, 1.22 (95% CI: 1.00–1.50); and CC genotype vs CT + TT genotype, 1.32 (95% CI: 1.09–1.61). Conclusions: HHEX rs5015480 represents a risk factor for the development of GDM, and pregnant women carrying the CC genotype have an increased risk of GDM.