Open AccessApplication of computed tomography, positron emission tomography-computed tomography, magnetic resonance imaging, endobronchial ultrasound, and mediastinoscopy in the diagnosis of mediastinal lymph node staging of non-small-cell lung cancer
Author(s) -
Longguo Zhang,
Fanqi Wu,
Rui Zhu,
Di Wu,
Yao Ding,
Zhongmei Zhang,
Ya Gao,
Yixin Wan
Publication year - 2020
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000019314
Subject(s) - medicine , mediastinoscopy , radiology , lung cancer , positron emission tomography , magnetic resonance imaging , lung cancer staging , mediastinal lymph node , lymph node , endoscopic ultrasound , receiver operating characteristic , tomography , mediastinum , cancer , pathology , metastasis
Background: Ruling out distant metastases, non-small cell lung cancer (NSCLC)treatment depends on the results of mediastinal node staging (N staging). Several diagnostic methods play central roles in mediastinal N staging. This study is intended to evaluate the existing diagnostic methods and report quality, and to search for the best method for staging mediastinal lymph nodes. Methods: We searched PubMed, Embase, and the Cochrane Library to identify relevant studies, including randomized controlled trials and retrospective studies. These studies report the application of computed tomography, positron emission tomography-computed tomography, magnetic resonance imaging, endobronchial ultrasound, and mediastinoscopy in the diagnosis of mediastinal lymph node staging of NSCLC. The quality of the literature was assessed using the Quality Assessment of Diagnostic Accuracy Study 2. The true positive, false positive, true negative, and false negative of each study was extracted. The corresponding sensitivity, specificity, and other indicators were calculated and the Summary Receiver Operating curve was established. Then, head-to-head and indirect comparison meta-analyses will be conducted. Results: The results of this study will be published in a peer-reviewed journal. Conclusion: This study will provide basis for mediastinal lymph node staging of non-small cell lung cancer. PROSPERO registration number: CRD42019145667