Open AccessLong-term survival and prognostic implications of patients with invasive breast cancer in southern Taiwan
Author(s) -
Shih-Chung Wu,
Ming-Chu Chiang,
Yun-Gang Lee,
Mei-Wen Wang,
Chuan-Fang Li,
TaoHsin Tung,
Hsiao-Hui Chen
Publication year - 2020
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000019122
Subject(s) - medicine , breast cancer , proportional hazards model , survival analysis , oncology , survival rate , distant metastasis , medical record , cancer registry , cancer , confidence interval , metastasis
Our objective in this study was to determine the survival rate of patients with invasive breast cancer and identify the prognostic factors related to all-cause mortality during a 10-year follow-up. Analysis was performed on the medical records of 2002 patients newly diagnosed with breast cancer at a medical center in southern Taiwan between 2006 and 2017. The Kaplan–Meier method and Cox regression analysis were used to estimate survival and the independence of prognostic factors associated with all-cause mortality. Among the 2002 patients, 257 expired during the 10-year follow-up period. The overall survival rates were as follows: 3 years (91.1%), 5 years (85.6%), and 10 years (77.9%). The median survival time was 120.41 months (95% confidence interval: 118.48–122.33 months). Older age, pathologic tumor status, regional lymph node metastasis, distant metastasis, grade/differentiation, treatment modalities, and hormone therapy were significantly related to all-cause mortality. This study identified several clinical factors related to all-cause mortality as well as its relationship to distant metastasis and poor differentiation. Early diagnosis and treatment aimed at preventing recurrence are the keys to survival.