Open AccessRisk factors for gallstone disease in Shanghai
Author(s) -
Qiyun Gu,
Guoqing Zhou,
Tao Xu
Publication year - 2020
Publication title -
medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 148
eISSN - 1536-5964
pISSN - 0025-7974
DOI - 10.1097/md.0000000000018754
Subject(s) - medicine , odds ratio , confidence interval , gastroenterology , univariate analysis , incidence (geometry) , logistic regression , alanine transaminase , risk factor , multivariate analysis , physics , optics
The purpose of this study was to evaluate related risk factors for gallstone disease in Shanghai. We analyzed successive physical examinations of 2288 adults who were recruited at the Jinshan Branch of the Sixth People's Hospital of Shanghai and Jinshan Hospital Affiliated to Fudan University Hospital from July 2010 to December 2012. The odds ratios (ORs) with 95% confidence intervals (CIs) were used to measure the influence factors on the risks of gallstone development. The incidence of gallstone disease was 4.11% (94/2,288). Older age (OR: 1.02; 95% CI: 1.00–1.03; P = .039), higher body weight (OR: 1.02; 95% CI: 1.00–1.04; P = .021), alanine transaminase activity (ALT) (OR: 1.02; 95% CI: 1.01–1.03; P = .001), total standard bicarbonate (SB) (OR: 1.04; 95% CI: 1.02–1.06; P < .001), free SB (OR: 1.17; 95% CI: 1.12–1.21; P < .001), and low density lipoprotein (LDL) levels (OR: 1.59; 95% CI: 1.32–1.91; P < .001) were associated with an increased risk of gallstone disease. Based on univariate logistic analysis, increased triglyceride (TG) levels were associated with a reduced risk of gallstone disease (OR: 0.76; 95% CI: 0.60–0.97; P = .024). The results of multivariable logistic regression analysis showed higher LDL levels correlated with an increased risk of gallstone disease (OR: 1.92; 95% CI: 1.31–2.81; P < .001), while age, weight, ALT, total SB, free SB, and TG levels did not affect the risk of gallstone disease. The although unadjusted results showed age, weight, ALT, total SB, free SB, TG, and LDL levels to be associated with the risk of gallstone disease, adjusting for potential factors revealed only increased LDL levels to be associated with an increased risk of gallstone disease.